Usted esta aquí
Inicio > Avances Médicos > Una nueva dimensión en trasplante

Una nueva dimensión en trasplante

En un avance tecnológico, los investigadores de ETH Zurich han anunciado el desarrollo de una nueva técnica que puede trasplantar mitocondrias, las diminutas centrales eléctricas de la célula, de una célula viva a otra con una eficiencia sin igual.

Así como el cuerpo humano se puede dividir en diferentes órganos, como el corazón, los pulmones, los riñones, el intestino o el hígado, nuestras células también constan de varios sistemas complementarios e interdependientes. Estos se conocen como orgánulos, es decir, órganos pequeños. Y así como a veces podemos agregar varias décadas a la vida de un paciente con enfermedad renal al trasplantar un riñón sano, algún día también podremos rejuvenecer células individuales al trasplantar componentes celulares.

Esta perspectiva puede parecer ciencia ficción, pero los nuevos hallazgos del grupo de investigación dirigido por Julia Vorholt en el Instituto de Microbiología de ETH Zurich sugieren que ahora ha alcanzado el punto de viabilidad técnica. En su investigación, publicada recientemente en la revista PLOS Biology, el grupo utilizó con éxito una ‘nanosjeringa’ que habían desarrollado previamente para trasplantar mitocondrias de una célula viva a otra.

Las mitocondrias son las diminutas centrales eléctricas de la célula donde tienen lugar los procesos de respiración celular, procesos que originalmente evolucionaron en las bacterias hace más de 2 mil millones de años. Con el tiempo, algunas bacterias se unieron a otras células para formar una comunidad interdependiente en un proceso llamado endosimbiosis, que desempeñó un papel importante en el desarrollo evolutivo de la vida en la Tierra. La endosimbiosis es, en última instancia, lo que condujo a la evolución de todos los organismos multicelulares que consisten en células complejas, desde hongos y plantas hasta animales, incluidos los humanos.

La endosimbiosis hizo que las bacterias antiguas evolucionaran gradualmente hacia las mitocondrias, los orgánulos que son responsables de la producción de energía en las células complejas de hoy. En las células humanas, las mitocondrias forman una red dinámica similar a un hilo. Utilizando nanojeringas cilíndricas que se desarrollaron especialmente para este estudio, los investigadores perforaron la membrana celular y succionaron las mitocondrias esféricas. Luego perforaron la membrana de una célula diferente y bombearon las mitocondrias de la nanojeringa hacia la célula receptora.

La posición de la nanojeringa se controla mediante la luz láser de un microscopio de fuerza atómica convertido. Un regulador de presión ajusta el flujo, lo que permite a los científicos transferir volúmenes increíblemente pequeños de líquido en el rango de femtolitros (millonésimas de millonésima de mililitro) durante los trasplantes de orgánulos.

Las mitocondrias trasplantadas también tienen una alta tasa de supervivencia, más del 80 por ciento. En la mayoría de las células, las mitocondrias inyectadas comienzan a fusionarse con la red filamentosa de la nueva célula 20 minutos después del trasplante. Esto es cierto en la mayoría de los casos, aunque en algunas células son víctimas del sistema de control de calidad de la célula huésped y se degradan.

En su artículo, los investigadores escriben que “la técnica presentada en este artículo facilitará las aplicaciones en diversas áreas de investigación en el futuro”. Es concebible que pueda usarse para rejuvenecer las células madre, cuya actividad metabólica disminuye a medida que envejecen. Pero el equipo de Vorholt actualmente persigue otros planes.

Más información: ETH Zurich

Mitochondria transplantation between living cells:

73 thoughts on “Una nueva dimensión en trasplante

  1. I intended to compose you one bit of remark to be able to thank you very much as before about the pleasant thoughts you’ve discussed at this time. It was generous with you in giving openly exactly what many people might have marketed for an e-book to generate some money on their own, mostly since you could have done it in case you wanted. Those advice also served to be the fantastic way to recognize that other individuals have similar passion just like mine to figure out good deal more concerning this problem. I’m sure there are numerous more pleasurable situations up front for those who scan through your blog.

  2. Thank you so much for providing individuals with remarkably splendid opportunity to read from this web site. It is often so useful plus stuffed with fun for me personally and my office peers to visit your blog at the least 3 times every week to find out the new guidance you have. And indeed, I am just certainly impressed with all the breathtaking suggestions you give. Some 1 points on this page are completely the very best we have all had.

  3. Thanks for your entire efforts on this website. My aunt enjoys setting aside time for investigations and it is obvious why. My spouse and i hear all of the dynamic ways you render informative tips and tricks via the web site and as well boost response from the others on the idea plus our own child has always been being taught a lot. Take advantage of the remaining portion of the year. You’re performing a stunning job.

  4. My wife and i felt happy Albert could conclude his basic research from your precious recommendations he acquired through your web pages. It’s not at all simplistic to simply be giving for free tips and tricks that some other people have been making money from. Therefore we take into account we need the website owner to thank for that. These explanations you have made, the simple website menu, the relationships you can give support to promote – it is all fantastic, and it’s making our son and us consider that that topic is enjoyable, and that is tremendously fundamental. Many thanks for all!

  5. I must show my affection for your generosity supporting people that absolutely need help with in this question. Your special commitment to getting the message across had been astonishingly important and has frequently allowed people just like me to attain their aims. Your personal important information denotes a lot a person like me and a whole lot more to my colleagues. Warm regards; from all of us.

  6. I’m just writing to let you know what a beneficial experience my friend’s princess encountered visiting yuor web blog. She discovered such a lot of things, not to mention what it’s like to have an amazing giving character to get other folks without difficulty have an understanding of various impossible issues. You undoubtedly surpassed our expected results. Thank you for producing those insightful, trusted, explanatory not to mention cool tips about that topic to Gloria.

  7. I needed to send you that bit of note to say thanks a lot the moment again with your awesome tricks you’ve shared on this page. It was extremely generous with you to provide unreservedly what a few individuals might have distributed for an ebook to end up making some profit on their own, principally now that you could have done it if you considered necessary. The concepts also acted as the fantastic way to be certain that some people have the same eagerness similar to my own to learn a great deal more pertaining to this matter. I’m sure there are numerous more enjoyable periods up front for folks who find out your site.

  8. I wanted to write you a little word to finally say thanks a lot once again with the amazing knowledge you’ve shared on this site. It was quite generous of people like you giving openly exactly what some people would have supplied for an electronic book to help with making some bucks on their own, especially since you could possibly have tried it in case you decided. The things likewise acted as the easy way to fully grasp the rest have the identical desire the same as my personal own to know the truth somewhat more when it comes to this condition. I’m certain there are a lot more fun times up front for people who looked at your blog.

  9. I have to express my thanks to you just for bailing me out of this condition. Right after browsing throughout the world-wide-web and seeing ideas which are not productive, I believed my life was gone. Being alive without the presence of strategies to the issues you’ve sorted out all through this short article is a serious case, as well as the ones which might have in a wrong way damaged my career if I hadn’t noticed the website. Your good mastery and kindness in maneuvering all the things was tremendous. I’m not sure what I would have done if I hadn’t discovered such a point like this. I am able to at this point look forward to my future. Thank you very much for this specialized and results-oriented help. I won’t be reluctant to recommend your web blog to any individual who requires guide on this problem.

  10. Thank you a lot for providing individuals with an extraordinarily pleasant opportunity to discover important secrets from this site. It can be very brilliant and as well , jam-packed with fun for me personally and my office co-workers to search your blog particularly thrice in one week to see the latest items you have. And lastly, we’re certainly satisfied with your stunning creative concepts you serve. Some 1 ideas in this article are undoubtedly the most impressive I’ve had.

  11. Thank you for all your work on this website. My aunt enjoys conducting investigation and it’s easy to see why. My partner and i hear all concerning the dynamic means you offer powerful items by means of the web blog and even foster response from some other people on this topic while our favorite child is without a doubt understanding a lot of things. Take pleasure in the remaining portion of the new year. You’re the one carrying out a fabulous job.

  12. I must show appreciation to you just for rescuing me from such a issue. Because of browsing throughout the internet and finding methods that were not pleasant, I believed my life was well over. Being alive without the approaches to the problems you’ve sorted out through your short article is a critical case, as well as the ones that would have in a negative way affected my entire career if I had not discovered your web page. Your personal know-how and kindness in controlling every part was very useful. I don’t know what I would’ve done if I had not discovered such a subject like this. It’s possible to at this moment look ahead to my future. Thank you very much for your high quality and effective help. I won’t be reluctant to propose your web blog to any individual who desires support on this problem.

  13. I not to mention my pals have been going through the good tactics on your web blog and suddenly got a terrible suspicion I never expressed respect to you for those techniques. My men appeared to be certainly happy to learn all of them and have pretty much been using those things. We appreciate you truly being well helpful as well as for deciding on this kind of extraordinary tips millions of individuals are really wanting to be aware of. My sincere apologies for not expressing appreciation to earlier.

  14. Needed to create you the very small remark to thank you once again with the splendid strategies you have shown on this website. This has been certainly incredibly generous of people like you to present freely what exactly a number of us could have sold for an ebook in order to make some profit for themselves, specifically considering that you might have done it in the event you decided. These secrets also acted to be the great way to comprehend most people have a similar passion like my very own to learn a lot more with reference to this problem. I know there are numerous more pleasant periods up front for individuals that see your site.

  15. My spouse and i were now thankful Albert could do his research with the ideas he acquired out of the web site. It is now and again perplexing to simply continually be making a gift of concepts many others could have been making money from. And we all do understand we need the blog owner to thank because of that. All the illustrations you have made, the straightforward web site navigation, the relationships your site assist to foster – it is mostly extraordinary, and it’s really helping our son in addition to us recognize that that theme is entertaining, and that’s seriously vital. Many thanks for the whole lot!

  16. I have to point out my love for your kind-heartedness for people who must have help with in this niche. Your personal dedication to getting the solution up and down had been particularly powerful and have frequently helped employees much like me to attain their desired goals. Your personal valuable tips and hints implies much to me and a whole lot more to my mates. Thanks a ton; from all of us.

  17. I enjoy you because of each of your efforts on this web site. My daughter loves participating in research and it’s really simple to grasp why. Most of us learn all concerning the lively tactic you give both interesting and useful tips and hints by means of the web site and therefore strongly encourage contribution from some others on the concern and our favorite princess is truly being taught a lot of things. Have fun with the rest of the new year. You are carrying out a first class job.

  18. My husband and i felt excited that Ervin could deal with his homework through the ideas he came across from your own web pages. It’s not at all simplistic to simply find yourself giving out procedures which usually the rest might have been selling. Therefore we take into account we now have you to appreciate because of that. All the explanations you made, the easy website menu, the friendships your site help to create – it’s got mostly astounding, and it’s letting our son in addition to us consider that the subject is brilliant, and that is especially pressing. Thank you for all the pieces!

  19. I precisely desired to thank you very much again. I do not know the things I might have handled without the actual techniques provided by you relating to my area of interest. Completely was a real depressing crisis in my opinion, however , considering a specialized approach you managed it forced me to jump for happiness. I’m happy for the work and even hope you know what an amazing job you were undertaking training the others thru your webblog. Probably you’ve never come across any of us.

  20. Thank you a lot for providing individuals with an extremely splendid chance to discover important secrets from this website. It really is very pleasurable and as well , stuffed with amusement for me personally and my office co-workers to search your website really thrice in one week to read through the fresh guides you have. And indeed, I am also actually satisfied with your incredible guidelines you give. Some 3 ideas in this article are honestly the most impressive we have ever had.

  21. I have to express my gratitude for your generosity for individuals that really need help with that concept. Your personal commitment to passing the solution all-around appears to be unbelievably helpful and have constantly encouraged employees much like me to get to their targets. Your personal warm and helpful report means a great deal a person like me and a whole lot more to my office colleagues. Thank you; from all of us.

Deja un comentario

Top